In Paris he enrolled in the College of Sainte-Barbe. In March 1530, upon completing his philosophical studies, he received a Master of Arts degree. Then from 1530 until 1534 he was an instructor in philosophy in the College of Beauvais, and from 1534 to 1536 a student of theology.
It was here, in the college as a student, that Francis met two other students who would have a huge influence on his life, Pierre Favre and Ignatius of Loyola. In 1526 Francis Xavier met Pierre and they became college roommates and friends. In 1529 they were joined by Ignatius of Loyola, who was then just new to the college.
Ignatius had been a former soldier and but was now devoting his life to God. He was 38 when he arrived in Paris with a view to improving his religious formation. He had already written a little book, based on his personal experiences, which he later called the Spiritual Exercises.
From the outset, Pierre Favre was impressed by Ignatius� good and spiritual way of life. Initially however, Francis Xavier did not take too kindly to Ignatius, even though Ignatius often came to the financial assistance of Francis, who, as a student, liked to live as a noble and lived much beyond his means.
Ignatius however had seen the potential that lay hidden beneath Francis� worldly ambitions. It is written that Francis heard a constant refrain from Ignatius: �What shall it profit a man if he gains the whole world but lose his own soul�(Matt. 16:26).
Francis Xavier was slowly and eventually won over by Ignatius of Loyola and the two would become life long friends and would found the then new religious order, the Society of Jesus (The Jesuits).
In Paris, Ignatius of Loyola, Francis Xavier and Pierre Favre were joined by four others: Simon Rodriguez, Jaime Laynez, Alphonso Salmeron and Nicolas Bobadilla. Together these seven companions were united in wanting to spread the Gospel and devoting their lives to the service of God. They decided that they would take vows of chastity and poverty and then make a pilgrimage to Jerusalem. On August 15th 1534 (the feast of the Assumption), in the chapel of Montmartre near Paris, these seven companions made their vows. This was an important step in the foundation of the Society of Jesus. Francis Xavier was later ordained a priest in Venice on June 24th 1537. He was then 31. He said his first Mass on September 30th of that year and according to those present he did so with tears in his eyes. He was indeed a very prayerful man. He prayed frequently and was often found deep in prayer. This was a quality that remained with him throughout his life.
Because of a war between the Turks and Venice, Francis and his companions were unable to begin their journey to the Holy Land. They went to Rome and offered their service to the Pope, Paul III.
At about this time, the King of Portugal made a request to the Pope for priests to minister to the needs of the growing number of subjects in the Portuguese overseas colonies. The Pope was hesitant. He was aware of the danger involved in treacherous nature of the sea-routes to the Portuguese colonies in the East. The Pope eventually agreed to send two priests but he left the choice of whom to Ignatius and his companions. Ignatius, finally but with some reluctance, called upon Francis Xavier to go to India. In 1540 Francis traveled from Rome to Lisbon. Here he spent a year, living at a hospice and helping to care for the sick there, visiting the poor, and visiting those in prison. Finally, in 1541, Francis Xavier set sail on his first missionary journey to India.
Francis Xavier left Lisbon on April 7, 1541(his 35th birthday), together with two other Jesuits on board the Santiago and in a fleet of five ships. The seas were rough and the conditions difficult. Francis spoke of the voyage later in a letter to his companions in Rome: ��I was seasick for two months and I was sorely tired for forty days off the coast of Guinea both because of the oppressive heat and the lack of winds.� From August of that year until March 1542, Francis remained in Mozambique because of the dangerous seas during wintertime. During his stay there Francis cared for the sick and the dying. He sail for Goa, leaving his two companions in Mozambique to care for the sick. He reached Goa, India, the capital of the then Portuguese colonies, on May 6th 1542. Because it was the monsoon climate, Francis was forced to spend the next four months in Goa. Finally in September he was able to travel to the Fishery coast in Southern india were had originally intended to go at the request of the King.
In September 1545, Francis Xavier set sail for Malacca in present day Malaysia. He used the same missionary methods he had developed in Goa and perfected in South India. He journeyed from Malacca to the islands of the Pacific Rim. It was a series of treacherous sea voyages. The land was not so safe either but he continued tirelessly and bravely.
On one of his journeys in these islands, he is known to have lost his crucifix during a storm. The distress which he experienced was intense but short-lived as his crucifix was found the next day - attached to a crab which was coming ashore. For the Jesuit and those with him at the time, it was nothing short of a miracle.
He returned to Malacca, where in 1547 he was introduced to Anjiro, a Japanese man who had sought refuge with the Portuguese and was christened as Paolo. This new convert expressed a strong desire to meet with this Francis Xavier, a priest all Malacca was talking about. With his moderate knowledge of Portuguese, Paolo impressed him. This was 'a man who wanted to know more about the faith'. Paolo convinced Francis that the Japanese would turn to Christ if they were convinced that Christians practiced what they preached. Francis made up his mind. He was going to Japan.
He returned to Goa in 1548 and formally took over teaching at the College of the Holy Faith in 1548. This college trained priests from all over Asia and the eastern seaboard of Africa. These 'natives of distant lands' travelled back to their homelands to carry on the work of the Church.
Francis Xavier reached Japan on July 27, 1549, but it wasn't until August 15 that he went ashore at Kagoshima, the principal port of the province of Satsuma, on the island of Kyushu. He was received in a friendly manner and was hosted by Paulo�s family until October 1550. From October to December 1550, he resided in Yamaguchi. Shortly before Christmas, he left for Kyoto, but failed to meet with the Emperor. He returned to Yamaguchi in March 1551. There he was permitted to preach by the daimyo, but not knowing the Japanese language he had to limit himself to reading aloud the translation of a catechism.
Francis worked for more than two years in Japan spreading the gospel and founding churches and saw his successor-Jesuits established. He then decided to return to India. Back in India in1552 he also began to make preparations for his next journey. With the help of a merchant Di�go Pereira, an old friend from Cochin, Francis was going to China.
On April 17 he set sail, with Di�go Pereira, leaving Goa on board the Santa Cruz for China. In early September 1552, the Santa Cruz reached the Chinese island of Shangchuan, 14 km away from the southern coast of mainland China.